The Most Experienced iPS Cell Team in the Nation
In July 2008, the Harvard Stem Cell Institute iPS Core Facility was created to accelerate research in the stem cell field by facilitating the derivation and distribution of induced pluripotent stem (iPS) cell lines. Disease-specific iPS cell lines provide us with an opportunity to study the mechanisms of disease and ultimately to develop new treatments.
In recent years, we have refined the iPS Core to better meet investigator needs. The iPS Core now has a fee-for-service business model to provide investigators with customized iPS derivation and genome editing based on the latest cutting-edge stem cell technologies.
- We offer three non-integrating technologies (Sendai virus, miRNA and modified mRNA, and episomal vector) for reprogramming of a variety of somatic cell types.
- In 2013, a new service was launched, offering the generation of genome engineered hESC or hiPS lines. We currently offer TALEN or CRISPR genome editing technologies to generate knock-out or knock-in lines for repair or introduction of mutations.
- The iPS Core also serves as a repository for Harvard hESC lines and both control and disease-specific hiPS cell lines.
All of these services are available to the global research community.